Article
Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon.
Mechanisms of development - 1 Jun 1997
Grindley J C, Hargett L K, Hill R E, Ross A, Hogan B L
Abstract excerpt
Pax6 expression in the diencephalon of the mouse embryo is restricted both antero-posteriorly and dorso-ventrally, with changes in level occurring at prosomere boundaries. Small eye (Pax6Sey-1Neu) mice homozygous for Pax6 mutations have multiple defects in early forebrain development. In the dien...
Topics
- Animals
- Base Sequence
- DNA-Binding Proteins
- Diencephalon
- Eye Proteins
- Female
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Homozygote
- In Situ Hybridization
- Mice
- Mice, Inbred ICR
- Models, Biological
- Mutagenesis, Insertional
- Mutation