Interchromosomal associations between alternatively expressed loci.

doi:10.1038/nature03574

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Article

Interchromosomal associations between alternatively expressed loci.

Nature - 2 Jun 2005

Spilianakis Charalampos G, Lalioti Maria D, Town Terrence, Lee Gap Ryol, Flavell Richard A

Abstract excerpt

The T-helper-cell 1 and 2 (T(H)1 and T(H)2) pathways, defined by cytokines interferon-gamma (IFN-gamma) and interleukin-4 (IL-4), respectively, comprise two alternative CD4+ T-cell fates, with functional consequences for the host immune system. These cytokine genes are encoded on different chromosomes. The recently described T(H)2 locus control region (LCR) coordinately regulates the T(H)2 cytokine genes by...

Topics

Alleles
Animals
Cell Nucleus
Cells, Cultured
Chromatin
Chromosome Positioning
Chromosomes, Mammalian
Cytokines
Deoxyribonuclease I
Enhancer Elements, Genetic
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Situ Hybridization, Fluorescence

Interferon-gamma

Interleukins

Locus Control Region

Mice

Mice, Inbred C57BL

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 15880101
DOI: 10.1038/nature03574

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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