Article
Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.
Immunity - 1 Mar 2001
Grogan J L, Mohrs M, Harmon B, Lacy D A, Sedat J W, Locksley R M
Abstract excerpt
Naive CD4+ T cells activated through TCR/CD28 under Th1 or Th2 conditions expressed canonical cytokine patterns irrespective of cell division. Only cells that had divided fewer than four times were capable of reexpressing alternative cytokines when restimulated under opposing conditions. Although T cells transcribed both IFN-gamma and IL-4 within hours in a Stat4-/Stat6-independent manner, neither T-bet nor...
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