Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

doi:10.1016/s1074-7613(01)00103-0

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

Immunity - 1 Mar 2001

Grogan J L, Mohrs M, Harmon B, Lacy D A, Sedat J W, Locksley R M

Abstract excerpt

Naive CD4+ T cells activated through TCR/CD28 under Th1 or Th2 conditions expressed canonical cytokine patterns irrespective of cell division. Only cells that had divided fewer than four times were capable of reexpressing alternative cytokines when restimulated under opposing conditions. Although T cells transcribed both IFN-gamma and IL-4 within hours in a Stat4-/Stat6-independent manner, neither T-bet nor...

Topics

Alleles
Animals
Cell Differentiation
Cell Division
Cells, Cultured
Cytokines
DNA-Binding Proteins
Female
GATA3 Transcription Factor
Gene Deletion
Gene Silencing
Granulocyte-Macrophage Colony-Stimulating Factor
Heterochromatin
Interferon-gamma

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-4

Interleukin-5

Kinetics

Lymphocyte Activation

Source

Open in PubMed

Identifiers

PMID: 11290331
DOI: 10.1016/s1074-7613(01)00103-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.