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Article

Basal chromatin modification at the IL-4 gene in helper T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2003

Grogan Jane L, Wang Zhi-En, Stanley Sarah, Harmon Brian, Loots Gaby G, Rubin Edward M, Locksley Richard M

Abstract excerpt

Chromatin immunoprecipitations in naive CD4, but not CD8, T cells, demonstrated association of the IL-4 promoter with acetylated histone. Histone modifications and rapid IL-4 transcription were absent in conserved noncoding sequence 1 (CNS-1)(-/-) cells lacking an 8-kb-distant enhancer in the IL-4/IL-13 intergenic region, but also in CD4(-/-) and Itk(-/-) cells, which have similar Th2 deficiencies. Histones...

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PMID: 14662870
DOI: 10.4049/jimmunol.171.12.6672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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