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Article

Long-range genomic interactions epigenetically regulate the expression of a cytokine receptor.

EMBO reports - 1 Sept 2012

Deligianni Chrysoula, Spilianakis Charalampos G

Abstract excerpt

Current research on the cytokine-mediated signalling towards the polarization and differentiation of a T-helper cell lineage lacks mechanistic insights on the transcriptional regulation of cytokine receptor genes. Here, we propose a new mechanism for the transcriptional regulation of the interferon gamma receptor 1 gene via long-range intrachromosomal interactions with the Ifnγ locus mediated by the protein CTCF....

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Share to CCCTC-Binding Factor
Share to CD4-Positive T-Lymphocytes
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

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Share to Interferon gamma Receptor

Share to Receptors, Interferon

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Source

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Identifiers

PMID: 22836578
DOI: 10.1038/embor.2012.112
PMCID: PMC3432804

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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