Article
Calcyclin (S100A6) expression is stimulated by agents evoking oxidative stress via the antioxidant response element.
Biochimica et biophysica acta - 15 May 2005
Leśniak Wiesława, Szczepańska Anna, Kuźnicki Jacek
Abstract excerpt
Calcyclin (S100A6) is a cell-specific, calcium binding protein of the S100 family whose expression is augmented in many types of cancer. By means of luciferase activity assays, RT-PCR and Northern blot hybridization, we established that transcription of S100A6 gene is increased by agents known to evoke oxidative stress. Mutation of the antioxidant response element (ARE) located at position -290/-281 of the...
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