Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estrogen response element-independent regulation of gene expression by genistein in intestinal cells.

Biochimica et biophysica acta - 19 Jun 2003

Hua Ping, Tsai Wan-Jung, Kuo Shiu-Ming

Abstract excerpt

Isoflavone, genistein, was shown to have antioxidant and antitumor activities. We have reported the stimulatory effect of genistein on the expression of antioxidant and metal-binding protein, metallothionein IIA (MTIIA), in human intestinal Caco-2 cells. Genistein has been shown to up-regulate the expression of other genes through estrogen response element (ERE) but the ERE sequence is not in the MTIIA promoter....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caco-2 Cells
Share to Copper
Share to Estrogen Receptor beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GC Rich Sequence

Share to Genistein

Share to Metallothionein

Share to Response Elements

Share to Sp1 Transcription Factor

Source

Identifiers

PMID: 12818423
DOI: 10.1016/s0167-4781(03)00075-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estrogen response element-independent regulation of gene expression by genistein in intestinal cells.PMID 12818423Read ↗

Genistein is an Efficient Estrogen in the Whole-Body throughout Mouse DevelopmentSemantic proximity Read ↗

Estrogen receptor-related receptor alpha 1 interacts with coactivator and constitutively activates the estrogen response elements of the human lactoferrin gene.Semantic proximity Read ↗

Estrogen induction of TGF-α is mediated by an estrogen response element composed of two imperfect palindromesSemantic proximity Read ↗

Genistein Activates Apolipoprotein A-I Gene Expression in the Human Hepatoma Cell Line Hep G2Semantic proximity Read ↗

Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) is induced by genistein through the expression of p53 in colorectal cancer cells.Semantic proximity Read ↗

A Possible Novel Mechanism of Action of Genistein and Daidzein for Activating Thyroid Hormone Receptor-Mediated Transcription.Semantic proximity Read ↗

Differentiation-dependent up-regulation of intestinal thiamin uptake: cellular and molecular mechanisms.Semantic proximity Read ↗

Calcyclin (S100A6) expression is stimulated by agents evoking oxidative stress via the antioxidant response element.Semantic proximity Read ↗

ESE-1, an Enterocyte-specific Ets Transcription Factor, Regulates MIP-3α Gene Expression in Caco-2 Human Colonic Epithelial CellsSemantic proximity Read ↗

A two-step screening method, using estrogen receptor-mediated transactivation, to measure estrogenicity in edibleSemantic proximity Read ↗

Biochemical Targets of the Isoflavone Genistein in Tumor Cell LinesSemantic proximity Read ↗

Genistein inhibits phorbol ester-induced NF-κB transcriptional activity and COX-2 expression by blocking the phosphorylation of p65/RelA in human mammary epithelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.