Article
Upstream stimulatory factor is involved in the regulation of the human calcyclin (S100A6) gene.
Biochimica et biophysica acta - 15 Dec 2000
Leśniak W, Jezierska A, Kuźnicki J
Abstract excerpt
Calcyclin (S100A6) is a calcium-binding protein overexpressed in several tumor cell lines including melanoma with high metastatic activity. The calcyclin gene promoter fragment -361/-167 activates transcription several fold when compared to the basal -167/+134 promoter fragment indicating the presence of enhancer element within -361/-167 bp region. By means of the electrophoretic mobility shift assay (EMSA) we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
