The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity.

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Article

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity.

The Journal of biological chemistry - 25 Jun 1991

Rushmore T H, Morton M R, Pickett C B

Abstract excerpt

We have characterized further the antioxidant responsive element (ARE) identified in the 5'-flanking region of the rat glutathione S-transferase Ya subunit gene and the NAD(P)H:quinone reductase gene by mutational and deletion analyses. Our data suggest that the sequence, 5'-puGTGACNNNGC-3' 3'-py...

Topics

Animals
Antioxidants
Base Sequence
Carcinoma, Hepatocellular
Chloramphenicol O-Acetyltransferase
Chromosome Deletion
Consensus Sequence
DNA, Neoplasm
Glutathione Transferase
Humans
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oxidation-Reduction

Polymerase Chain Reaction

Promoter Regions, Genetic

Quinone Reductases

Rats

Source

Open in PubMed

Identifiers

PMID: 1646813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1646813-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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