Article
Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells.
Nature - 7 Nov 2002
Tauchi Hiroshi, Kobayashi Junya, Morishima Ken-ichi, van Gent Dik C, Shiraishi Takahiro, Verkaik Nicole S, vanHeems Diana, Ito Emi, Nakamura Asako, Sonoda Eiichiro, Takata Minoru, Takeda Shunichi, Matsuura Shinya, Komatsu Kenshi
Abstract excerpt
Double-strand breaks occur during DNA replication and are also induced by ionizing radiation. There are at least two pathways which can repair such breaks: non-homologous end joining and homologous recombination (HR). Although these pathways are essentially independent of one another, it is possible that the proteins Mre11, Rad50 and Xrs2 are involved in both pathways in Saccharomyces cerevisiae. In vertebrate...
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