Article
Characterization of the interaction between interleukin-13 and interleukin-13 receptors.
The Journal of biological chemistry - 1 Jul 2005
Arima Kazuhiko, Sato Kazuo, Tanaka Go, Kanaji Sachiko, Terada Tohru, Honjo Eijiro, Kuroki Ryota, Matsuo Yo, Izuhara Kenji
Abstract excerpt
Interleukin-13 (IL-13) possesses two types of receptor: the heterodimer, composed of the IL-13Ralpha1 chain (IL-13Ralpha1) and the IL-4Ralpha chain (IL-4Ralpha), transducing the IL-13 signals; and the IL-13Ralpha2 chain (IL-13Ralpha2), acting as a nonsignaling "decoy" receptor. Extracellular portions of both IL-13Ralpha1 and IL-13Ralpha2 are composed of three fibronectin type III domains, D1, D2, and D3, of which...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
