Article
Interleukin 13 receptors as biochemical markers in atopic patients.
Journal of investigational allergology & clinical immunology - 1 Jan 2011
Hussein Y M, Ahmad A S, Ibrahem M M, Elsherbeny H M, Shalaby S M, El-Shal A S, Sabbah N A
Abstract excerpt
BACKGROUND: Interleukin (IL) 13, a type 2 helper T cell (T(H)2), is an important regulator of inflammatory immune responses. It mediates its action through a receptor complex consisting of IL-13Ralpha1 and IL-4Ralpha. IL-13Ralpha2 binds IL-13 with high affinity and is thought to act primarily as a decoy receptor, sequestering IL-13 and thus inhibiting its action. Our aim was to clarify the role of these receptors...
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