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Article

A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor.

BMC biology - 26 Apr 2006

Kraich Michael, Klein Markus, Patiño Edwin, Harrer Henning, Nickel Joachim, Sebald Walter, Mueller Thomas D

Abstract excerpt

BACKGROUND: Interleukin 4 (IL-4) is a key regulator of the immune system and an important factor in the development of allergic hypersensitivity. Together with interleukin 13 (IL-13), IL-4 plays an important role in exacerbating allergic and asthmatic symptoms. For signal transduction, both cytokines can utilise the same receptor, consisting of the IL-4Ralpha and the IL-13Ralpha1 chain, offering an explanation...

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PMID: 16640778
DOI: 10.1186/1741-7007-4-13
PMCID: PMC1479839

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Source receipt: pubmed, retrieved 7 Sept 2026.

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