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Article

Interleukin 13 mutants of enhanced avidity toward the glioma-associated receptor, IL13Ralpha2.

Neoplasia (New York, N.Y.) - 1 Jan 2000

Madhankumar A B, Mintz Akiva, Debinski Waldemar

Abstract excerpt

Interleukin 13 (IL13) binds a receptor that is highly overexpressed in malignant gliomas, IL13Ralpha2. IL13 protein is composed of four helices: alpha-helix A, B, C, and D, and we found a new "hot spot" in alpha-helix D that is crucial for the binding of IL13 to IL13Ralpha2. Lys-105 plus Lys-106...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15068667
DOI: 10.1016/s1476-5586(04)80049-6
PMCID: PMC1508627

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15068667-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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