Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction.

doi:10.1002/j.1460-2075.1993.tb05927.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction.

The EMBO journal - 1 Jul 1993

Zurawski S M, Vega F, Huyghe B, Zurawski G

Abstract excerpt

Interleukin-4 (IL-4) and interleukin-13 (IL-13) are two cytokines that are secreted by activated T cells and have similar effects on monocytes and B cells. We describe a mutant form of human interleukin-4 (hIL-4) that competitively antagonizes both hIL-4 and human interleukin-13 (hIL-13). The ami...

Topics

Amino Acid Sequence
Animals
Base Sequence
Binding, Competitive
Cell Line
Humans
Interleukin-13
Interleukin-13 Receptor alpha1 Subunit
Interleukin-4
Interleukins
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligodeoxyribonucleotides

Receptors, Immunologic

Receptors, Interleukin

Receptors, Interleukin-13

Receptors, Interleukin-4

Receptors, Mitogen

Source

Open in PubMed Open full text

Identifiers

PMID: 8101483
DOI: 10.1002/j.1460-2075.1993.tb05927.x
PMCID: PMC413514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8101483-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction.PMID 8101483Read ↗

Commentary: IL-4 and IL-13 receptors and signaling.Semantic proximity Read ↗

Characterization of the interaction between interleukin-13 and interleukin-13 receptors.Semantic proximity Read ↗

Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness.Semantic proximity Read ↗

A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor.Semantic proximity Read ↗

Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer.Semantic proximity Read ↗

Two different IL-13 receptor chains are expressed in normal human skin fibroblasts, and IL-4 and IL-13 mediate signal transduction through a common pathwaySemantic proximity Read ↗

Solution structure of human IL-13 and implication for receptor binding.Semantic proximity Read ↗

Structure, binding, and antagonists in the IL-4/IL-13 receptor systemSemantic proximity Read ↗

Alanine-scanning Mutagenesis of α-Helix D Segment of Interleukin-13 Reveals New Functionally Important Residues of the CytokineSemantic proximity Read ↗

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency.Semantic proximity Read ↗

Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain.Semantic proximity Read ↗

Species-specific agonist/antagonist activities of human interleukin-4 variants suggest distinct ligand binding properties of human and murine common receptor gamma chain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.