Article
Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness.
The Journal of biological chemistry - 4 Sept 2009
Ito Takachika, Suzuki Shoichi, Kanaji Sachiko, Shiraishi Hiroshi, Ohta Shoichiro, Arima Kazuhiko, Tanaka Go, Tamada Taro, Honjo Eijiro, Garcia K Christopher, Kuroki Ryota, Izuhara Kenji
Abstract excerpt
Both interleukin-4 (IL-4) and IL-13 can bind to the shared receptor composed of the IL-4 receptor alpha chain and the IL-13 receptor alpha1 chain (IL-13Ralpha1); however, the mechanisms by which these ligands bind to the receptor chains are different, enabling the principal functions of these ligands to be different. We have previously shown that the N-terminal Ig-like domain in IL-13Ralpha1, called the D1...
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