Article
Anxious and hyperactive phenotype following brief ischemic episodes in mice.
Biological psychiatry - 15 May 2005
Winter Benjamin, Juckel Georg, Viktorov Ilya, Katchanov Juri, Gietz Andrea, Sohr Reinhard, Balkaya Mustafa, Hörtnagl Heide, Endres Matthias
Abstract excerpt
BACKGROUND: Poststroke emotional and behavioral abnormalities have an impact on outcome but have scarcely been characterized in animal models. We tested whether brief ischemic episodes induce behavioral changes in mice. METHODS: 129/Sv mice were subjected to 30-min occlusion of left or right middle cerebral artery (MCAo) followed by reperfusion or sham operation (n = 9 or 10 per group). Eight to ten weeks later,...
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