Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase.

doi:10.1126/science.7522345

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Article

Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase.

Science (New York, N.Y.) - 23 Sept 1994

Huang Z, Huang P L, Panahian N, Dalkara T, Fishman M C, Moskowitz M A

Abstract excerpt

The proposal that nitric oxide (NO) or its reactant products mediate toxicity in brain remains controversial in part because of the use of nonselective agents that block NO formation in neuronal, glial, and vascular compartments. In mutant mice deficient in neuronal NO synthase (NOS) activity, in...

Topics

Amino Acid Oxidoreductases
Animals
Arginine
Brain
Brain Ischemia
Cerebral Infarction
Cerebrovascular Circulation
Female
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mutation
Neurons
Nitric Oxide
Nitric Oxide Synthase
Nitroarginine

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