Article
Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase.
Science (New York, N.Y.) - 23 Sept 1994
Huang Z, Huang P L, Panahian N, Dalkara T, Fishman M C, Moskowitz M A
Abstract excerpt
The proposal that nitric oxide (NO) or its reactant products mediate toxicity in brain remains controversial in part because of the use of nonselective agents that block NO formation in neuronal, glial, and vascular compartments. In mutant mice deficient in neuronal NO synthase (NOS) activity, infarct volumes decreased significantly 24 and 72 hours after middle cerebral artery occlusion, and the neurological...
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