Increased severity of stroke in CB1 cannabinoid receptor knock-out mice.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Increased severity of stroke in CB1 cannabinoid receptor knock-out mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Nov 2002

Parmentier-Batteur Sophie, Jin Kunlin, Mao Xiao Ou, Xie Lin, Greenberg David A

Abstract excerpt

Endogenous cannabinoid signaling pathways have been implicated in protection of the brain from hypoxia, ischemia, and trauma, but the mechanism for these protective effects is uncertain. We found that in CB1 cannabinoid receptor knock-out mice, mortality from permanent focal cerebral ischemia was increased, infarct size and neurological deficits after transient focal cerebral ischemia were more severe, cerebral...

Topics

Animals
Blood Flow Velocity
Blood Pressure
Brain
Cerebrovascular Circulation
Disease Models, Animal
Genotype
Heterozygote
Homozygote
Infarction, Middle Cerebral Artery
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

N-Methylaspartate

Neurons

Phenotype

Receptors, Cannabinoid

Receptors, Drug

Source

Open in PubMed Open full text

Identifiers

PMID: 12427832
PMCID: PMC6757835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased severity of stroke in CB1 cannabinoid receptor knock-out mice.PMID 12427832Read ↗

CB2 cannabinoid receptors modulate HIF-1α and TIM-3 expression in a hypoxia-ischemia mouse model.Semantic proximity Read ↗

Differences in vulnerability to permanent focal cerebral ischemia among 3 common mouse strains.Semantic proximity Read ↗

Targeted hsp70.1 disruption increases infarction volume after focal cerebral ischemia in mice.Semantic proximity Read ↗

Deficiency of intercellular adhesion molecule 1 attenuates microcirculatory disturbance and infarction size in focal cerebral ischemia.Semantic proximity Read ↗

Minimal ischaemic neuronal damage and HSP70 expression in MF1 strain mice following bilateral common carotid artery occlusion.Semantic proximity Read ↗

Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase.Semantic proximity Read ↗

Soluble guanylate cyclase alpha1beta1 limits stroke size and attenuates neurological injury.Semantic proximity Read ↗

Mouse strain differences in susceptibility to cerebral ischemia are related to cerebral vascular anatomy.Semantic proximity Read ↗

Attenuated hippocampal damage after global cerebral ischemia in mice mutant in neuronal nitric oxide synthase.Semantic proximity Read ↗

Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189.Semantic proximity Read ↗

Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans.Semantic proximity Read ↗

A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.