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Article

Proinflammatory phenotype of vascular smooth muscle cells: role of efficient Toll-like receptor 4 signaling.

American journal of physiology. Heart and circulatory physiology - 1 Sept 2005

Yang Xin, Coriolan Daniel, Murthy Vanishree, Schultz Kelly, Golenbock Douglas T, Beasley Debbie

Abstract excerpt

Recent evidence supports a role of Toll-like receptor (TLR) signaling in the development of atherosclerotic lesions. In this study, we tested whether TLR4 signaling promotes a proinflammatory phenotype in human and mouse arterial smooth muscle cells (SMC), characterized by increased cytokine and chemokine synthesis and increased TLR expression. Human arterial SMC were found to express mRNA encoding TLR4 and the...

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Source

Identifiers

PMID: 15863460
DOI: 10.1152/ajpheart.00143.2005

Genes

TLR4
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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