Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endogenous interleukin-1 alpha promotes a proliferative and proinflammatory phenotype in human vascular smooth muscle cells.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2007

Schultz Kelly, Murthy Vanishree, Tatro Jeffrey B, Beasley Debbie

Abstract excerpt

During vascular disease and following injury, vascular smooth muscle cells (VSMC) proliferate and produce inflammation-promoting cytokines and chemokines. Similar phenotypic changes can be elicited in vitro by activation of Toll-like receptors (TLR) within VSMC. TLR-activated VSMC also produce IL-1 alpha, but it is unknown whether endogenous IL-1 alpha stimulates VSMC in an autocrine manner. Here we tested the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autocrine Communication
Share to Chemokine CCL2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coronary Vessels

Share to Fibroblast Growth Factor 2

Share to Interleukin-1alpha

Share to Platelet-Derived Growth Factor

Share to Toll-Like Receptor 3

Source

Identifiers

PMID: 17293495
DOI: 10.1152/ajpheart.00700.2006

Genes

EGF
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endogenous interleukin-1 alpha promotes a proliferative and proinflammatory phenotype in human vascular smooth muscle cells.PMID 17293495Read ↗

Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells.Semantic proximity Read ↗

Proinflammatory phenotype of vascular smooth muscle cells: role of efficient Toll-like receptor 4 signaling.Semantic proximity Read ↗

Macrophage migration inhibitory factor triggers vascular smooth muscle cell dedifferentiation by a p68-serum response factor axis.Semantic proximity Read ↗

Thematic review series: The immune system and atherogenesis. Cytokines affecting endothelial and smooth muscle cells in vascular disease.Semantic proximity Read ↗

Thrombin promotes proinflammatory phenotype in human vascular smooth muscle cell.Semantic proximity Read ↗

Molecular signatures determining coronary artery and saphenous vein smooth muscle cell phenotypes: distinct responses to stimuli.Semantic proximity Read ↗

Paracrine signalling from monocytes enables desirable extracellular matrix accumulation and temporally appropriate phenotype of vascular smooth muscle cell-like cells derived from adipose stromal cells.Semantic proximity Read ↗

miRNA-34a reduces neointima formation through inhibiting smooth muscle cell proliferation and migration.Semantic proximity Read ↗

Toll-like receptors 4 induces expression of matrix metalloproteinase-9 in human aortic smooth muscle cells.Semantic proximity Read ↗

BMP-2 and -4 produced by vascular smooth muscle cells from atherosclerotic lesions induce monocyte chemotaxis through direct BMPRII activation.Semantic proximity Read ↗

C1q/TNF-related protein 1 prevents neointimal formation after arterial injury.Semantic proximity Read ↗

Interleukin-1β modulates smooth muscle cell phenotype to a distinct inflammatory state relative to PDGF-DD via NF-κB-dependent mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.