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Article

Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis.

Journal of vascular research - 1 Jan 2010

Orr Anthony Wayne, Hastings Nicole E, Blackman Brett R, Wamhoff Brian R

Abstract excerpt

Vascular smooth muscle cell (SMC) phenotypic modulation plays a key role in atherosclerosis and is classically defined as a switch from a 'contractile' phenotype to a 'synthetic' phenotype, whereby genes that define the contractile SMC phenotype are suppressed and proliferation and/or migratory mechanisms are induced. There is also evidence that SMCs may take on a 'proinflammatory' phenotype, whereby SMCs secrete...

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Source

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Identifiers

PMID: 19851078
DOI: 10.1159/000250095
PMCID: PMC2842170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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