Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of let-7d-5p miRNA modulates aortic smooth muscle inflammatory signaling and phenotypic switching.

Atherosclerosis - 1 Aug 2024

Vartak Tanwi, Giardini Elena, Kelly Daniel, Moran Bruce, Kennedy Ciarán, Barry Mary, Godson Catherine, Brennan Eoin

Abstract excerpt

BACKGROUND AND AIMS: Activation of vascular smooth muscle cell inflammation is recognised as an important early driver of vascular disease. We have previously identified the let-7 miRNA family as important regulators of inflammation in in vitro and in vivo models of atherosclerosis. Here we investigated a dual statin/let-7d-5p miRNA combination therapy approach to target human aortic SMC (HAoSMC) activation and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to Atorvastatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Inflammation Mediators

Share to Lovastatin

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 38796407
DOI: 10.1016/j.atherosclerosis.2024.117573

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of let-7d-5p miRNA modulates aortic smooth muscle inflammatory signaling and phenotypic switching.PMID 38796407Read ↗

MicroRNA‐26a is a novel regulator of vascular smooth muscle cell functionSemantic proximity Read ↗

Circ-ABCA1 promotes oxidized low-density lipoprotein-induced inflammation and phenotypic switch in vascular smooth muscle cells.Semantic proximity Read ↗

miRNA Regulation of Cell Phenotype and Parietal Remodeling in Atherosclerotic and Non-Atherosclerotic Aortic Aneurysms: Differences and Similarities.Semantic proximity Read ↗

Identification of the CeRNA axis of circ_0000006/miR-483-5p/KDM2B in the progression of aortic aneurysm to aorta dissection.Semantic proximity Read ↗

miR-146a-5p mediates atherogenic signalling from immune to vascular cells.Semantic proximity Read ↗

A predictive insight into the ATRNL1-mediated ceRNA network driving abdominal aortic aneurysm progression via VSMC phenotypic switching.Semantic proximity Read ↗

MicroRNAs in atherosclerosis.Semantic proximity Read ↗

Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders.Semantic proximity Read ↗

Single-cell RNA sequencing identifies an Il1rn+/Trem1+ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissectionSemantic proximity Read ↗

Deciphering the Intercellular Communication Between Immune Cells and Altered Vascular Smooth Muscle Cell Phenotypes in Aortic Aneurysm From Single-Cell Transcriptome DataSemantic proximity Read ↗

Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models.Semantic proximity Read ↗

Long Non-Coding RNA Function in Smooth Muscle Cell Plasticity and Atherosclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.