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It takes a village: microbiota, parainflammation, paligenosis and bystander effects in colorectal cancer initiation

1 May 2021

Abstract excerpt

Sporadic colorectal cancer (CRC) is a leading cause of worldwide cancer mortality. It arises from a complex milieu of host and environmental factors, including genetic and epigenetic changes in colon epithelial cells that undergo mutation, selection, clonal expansion, and transformation. The gut microbiota has recently gained increasing recognition as an additional important factor contributing to CRC. Several...

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PMID: 33969420
DOI: 10.1242/dmm.048793

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