Article
Clonal expansions in ulcerative colitis identify patients with neoplasia.
Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 2009
Salk Jesse J, Salipante Stephen J, Risques Rosa Ana, Crispin David A, Li Lin, Bronner Mary P, Brentnall Teresa A, Rabinovitch Peter S, Horwitz Marshall S, Loeb Lawrence A
Abstract excerpt
Chronic inflammation predisposes to a variety of human cancers. Affected tissues slowly accumulate mutations, some of which affect growth regulation and drive successive waves of clonal evolution, whereas a far greater number are functionally neutral and serve only to passively mark expanding clones. Ulcerative colitis (UC) is an inflammatory bowel disease, in which up to 10% of patients eventually develop colon...
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