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Article

Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming.

Stem cells (Dayton, Ohio) - 1 Dec 2009

Wei Zong, Yang Yang, Zhang Peilin, Andrianakos Rosemary, Hasegawa Kouichi, Lyu Jungmook, Chen Xi, Bai Gang, Liu Chunming, Pera Martin, Lu Wange

Abstract excerpt

Somatic cells can be reprogrammed to induced pluripotent stem (iPS) cells by ectopic expression of specific sets of transcription factors. Oct4, Sox2, and Klf4, factors that share many target genes in embryonic stem (ES) cells, are critical components in various reprogramming protocols. Nevertheless, it remains unclear whether these factors function together or separately in reprogramming. Here we show that Klf4...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19816951
DOI: 10.1002/stem.231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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