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Article

Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jul 2005

Feuk Lars, McCarthy Shane, Andersson Björn, Prince Jonathan A, Brookes Anthony J

Abstract excerpt

Genetic and biological studies point to a role for insulin-degrading enzyme (IDE) in Alzheimer's disease (AD). Two SNP-based studies recently reported evidence for association with AD using markers in a approximately 270 kb haplotype block on chromosome 10q. This haplotype block region harbors three known genes; insulin-degrading enzyme (IDE), kinesin family member 11 (KIF11), and hematopoietically expressed...

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Topics

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Share to Alzheimer Disease
Share to Chromosomes, Human, Pair 10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Haplotypes

Share to Homeodomain Proteins

Share to Insulysin

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Share to Linkage Disequilibrium

Source

Identifiers

PMID: 15858821
DOI: 10.1002/ajmg.b.30172

Genes

IDE
KIF11
HHEX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease.PMID 15858821Read ↗

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