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Article

Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease.

Human mutation - 1 Apr 2004

Ertekin-Taner Nilüfer, Allen Mariet, Fadale Daniel, Scanlin Leah, Younkin Linda, Petersen Ronald C, Graff-Radford Neill, Younkin Steven G

Abstract excerpt

Risk for late onset Alzheimer disease (LOAD) and plasma amyloid beta levels (Abeta42; encoded by APP), an intermediate phenotype for LOAD, show linkage to chromosome 10q. Several strong candidate genes (VR22, PLAU, IDE) lie within the 1-lod support interval for linkage. Others have independently identified haplotypes in the chromosome 10q region harboring IDE that show highly significant association with...

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Source

Identifiers

PMID: 15024728
DOI: 10.1002/humu.20016

Genes

IDE
APP
HHEX
PLAU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease.PMID 15024728Read ↗

Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.Semantic proximity Read ↗

Association between variants in IDE-KIF11-HHEX and plasma amyloid β levels.Semantic proximity Read ↗

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Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's DiseaseSemantic proximity Read ↗

Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene.Semantic proximity Read ↗

Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain.Semantic proximity Read ↗

Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease.Semantic proximity Read ↗

Association studies testing for risk for late-onset Alzheimer's disease with common variants in the beta-amyloid precursor protein (APP).Semantic proximity Read ↗

Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.Semantic proximity Read ↗

An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.Semantic proximity Read ↗

Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease.Semantic proximity Read ↗

Susceptibility locus for Alzheimer's disease on chromosome 10.Semantic proximity Read ↗

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