Article
Global gene expression as a function of germline genetic variation.
Human molecular genetics - 15 Jun 2005
French Deborah, Wilkinson Mark R, Yang Wenjian, de Chaisemartin Luc, Cook Edwin H, Das Soma, Ratain Mark J, Evans William E, Downing James R, Pui Ching-Hon, Relling Mary V
Abstract excerpt
Common, functional, germline genetic polymorphisms have been associated with clinical cancer outcomes. Little attention has been paid to the potential phenotypic consequences of germline genetic variation on downstream genes. We determined the germline status of 16 well-characterized functional polymorphisms in 126 children with newly diagnosed acute lymphoblastic leukemia (ALL). We assessed whether global gene...
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