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Research Resource: Transcriptional Response to Glucocorticoids in Childhood Acute Lymphoblastic Leukemia

11 Nov 2011

Abstract excerpt

Glucocorticoids (GC) induce apoptosis in lymphoblasts and are thus essential in the treatment of acute lymphoblastic leukemia (ALL). Their effects result from gene regulations via the GC receptor (NR3C1/GR), but it is unknown how these changes evolve, what the primary GR targets are, and to what extent responses differ between ALL subtypes and nonlymphoid malignancies. We delineated the transcriptional response...

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PMID: 22074950
DOI: 10.1210/me.2011-1213

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