Article
Genome-wide approach to identify risk factors for therapy-related myeloid leukemia.
Leukemia - 1 Feb 2006
Bogni A, Cheng C, Liu W, Yang W, Pfeffer J, Mukatira S, French D, Downing J R, Pui C-H, Relling M V
Abstract excerpt
Using a target gene approach, only a few host genetic risk factors for treatment-related myeloid leukemia (t-ML) have been defined. Gene expression microarrays allow for a more genome-wide approach to assess possible genetic risk factors for t-ML. We assessed gene expression profiles (n=12 625 probe sets) in diagnostic acute lymphoblastic leukemic cells from 228 children treated on protocols that included...
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