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Article

Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2002

Krajinovic Maja, Labuda Damian, Mathonnet Geraldine, Labuda Marcin, Moghrabi Albert, Champagne Josette, Sinnett Daniel

Abstract excerpt

PURPOSE: The most common childhood malignancy, acute lymphoblastic leukemia (ALL), remains the leading cause of cancer-related death in children because of resistant cases in which underlying predisposing factors are poorly understood. The interindividual variation in the activity of xenobiotic metabolizing enzymes that modify individual somatic mutation burden in the context of environmental exposure was shown...

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Source

Identifiers

PMID: 11895912

Genes

NQO1
GSTM1
GSTP1
GSTT1
MPO
NAT1
NAT2
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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