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Article

Childhood acute lymphoblastic leukemia: genetic determinants of susceptibility and disease outcome.

Reviews on environmental health - 1 Jan 2000

Krajinovic M, Labuda D, Sinnett D

Abstract excerpt

The origin of acute lymphoblastic leukemia (ALL), the most common pediatric cancer, can be explained by a combination of genetic factors and environmental exposure. The environmental toxicants to which an individual is exposed are biotransformed and eliminated from the body after metabolic conversion mediated by Phase I and Phase II xenobiotic-metabolizing enzymes. Phase I enzymes catalyze hydroxylation,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12041882
DOI: 10.1515/reveh.2001.16.4.263

Genes

NQO1
GSTM1
GSTP1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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