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Article

Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac.

Oncogene - 30 Jun 2005

Dupuy Aurélien G, L'Hoste Sébastien, Cherfils Jacqueline, Camonis Jacques, Gaudriault Georges, de Gunzburg Jean

Abstract excerpt

Rap1 is a Ras-related GTPase that is principally involved in integrin- and E-cadherin-mediated adhesion. Rap1 is transiently activated in response to many incoming signals via a large family of guanine nucleotide exchange factors (GEFs). The lack of potent Rap1 dominant-negative mutants has limited our ability to decipher Rap1-dependent pathways; we have therefore developed a procedure to generate such mutants...

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PMID: 15856025
DOI: 10.1038/sj.onc.1208647

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EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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