Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure and regulation of the cAMP-binding domains of Epac2.

Nature structural biology - 1 Jan 2003

Rehmann Holger, Prakash Balaji, Wolf Eva, Rueppel Alma, de Rooij Johan, Bos Johannes L, Wittinghofer Alfred

Abstract excerpt

Cyclic adenosine monophosphate (cAMP) is a universal second messenger that, in eukaryotes, was believed to act only on cAMP-dependent protein kinase A (PKA) and cyclic nucleotide-regulated ion channels. Recently, guanine nucleotide exchange factors specific for the small GTP-binding proteins Rap1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP-Dependent Protein Kinases
Share to Guanine Nucleotide Exchange Factors
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to Cyclic AMP

Share to Protein Conformation

Share to rap GTP-Binding Proteins

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 12469113
DOI: 10.1038/nsb878

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12469113-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure and regulation of the cAMP-binding domains of Epac2.PMID 12469113Read ↗

Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac.Semantic proximity Read ↗

Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities.Semantic proximity Read ↗

Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac.Semantic proximity Read ↗

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.Semantic proximity Read ↗

Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP.Semantic proximity Read ↗

Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A.Semantic proximity Read ↗

Rap-Interacting Proteins are Key Players in the Rap Symphony OrchestraSemantic proximity Read ↗

Spatial control of Epac2 activity by cAMP and Ca2+-mediated activation of Ras in pancreatic β cells.Semantic proximity Read ↗

Structure-Guided Design of Selective Epac1 and Epac2 AgonistsSemantic proximity Read ↗

Phosphodiesterase Type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteinsSemantic proximity Read ↗

Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide SignalingSemantic proximity Read ↗

Cyclic nucleotide signalling: a molecular approach to drug discovery for Alzheimer's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.