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Article

Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac.

The Journal of biological chemistry - 27 Jun 2003

Rehmann Holger, Rueppel Alma, Bos Johannes L, Wittinghofer Alfred

Abstract excerpt

Epac1 is a guanine nucleotide exchange factor (GEF) for the small GTPase Rap1 that is directly activated by cAMP. This protein consists of a regulatory region with a cAMP-binding domain and a catalytic region that mediates the GEF activity. Epac is inhibited by an intramolecular interaction betwe...

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Source

Identifiers

PMID: 12707263
DOI: 10.1074/jbc.M301680200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12707263-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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