Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).

Oncogene - 14 Aug 1997

van den Berghe N, Cool R H, Horn G, Wittinghofer A

Abstract excerpt

A catalytically active fragment of the Rap-specific guanine-nucleotide exchange factor C3G was expressed in E coli. It was purified and its interaction with GTP-binding proteins was investigated using fluorescence spectroscopy. C3G stimulates GDP dissociation from Rap1, but not from Rap2, neither from Bud1, which is believed to be the yeast homologue of Rap1 nor from all other proteins of the human Ras-subfamily....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Escherichia coli
Share to GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Mutation

Share to Peptide Fragments

Share to Phosphoprotein Phosphatases

Share to Proteins

Source

Identifiers

PMID: 9266971
DOI: 10.1038/sj.onc.1201407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).PMID 9266971Read ↗

The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster.Semantic proximity Read ↗

Signalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factorSemantic proximity Read ↗

Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac.Semantic proximity Read ↗

Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator.Semantic proximity Read ↗

Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins.Semantic proximity Read ↗

Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.Semantic proximity Read ↗

The GTPase-activating protein Rap1GAP uses a catalytic asparagine.Semantic proximity Read ↗

RAS residues that are distant from the GDP binding site play a critical role in dissociation factor-stimulated release of GDP.Semantic proximity Read ↗

Properties of the SDC25 C-domain, a GDP to GTP exchange factor of RAS proteins and in vitro modulation of adenylyl cyclase.Semantic proximity Read ↗

Biochemical characterization of yeast RAS2 mutants reveals a new region of ras protein involved in the interaction with GTPase-activating proteins.Semantic proximity Read ↗

Overexpression of Bud5p can suppress mutations in the Gsp1p guanine nucleotide exchange factor Prp20p in Saccharomyces cerevisiae.Semantic proximity Read ↗

The nucleotide exchange factor Cdc24p may be regulated by auto-inhibition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.