Article
Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma.
Diabetes - 1 May 2005
Risérus Ulf, Tan Garry D, Fielding Barbara A, Neville Matt J, Currie Jenny, Savage David B, Chatterjee V Krishna, Frayn Keith N, O'Rahilly Stephen, Karpe Fredrik
Abstract excerpt
Fatty acid desaturases such as steaoryl-CoA desaturase (SCD) convert saturated to unsaturated fatty acids and are involved in lipogenesis. Observational and animal data suggest that SCD-1 activity is related to insulin sensitivity. However, the effects of insulin-sensitizing drugs on SCD gene expression and desaturase activities are unknown in humans. In a randomized, placebo-controlled, double-blind, crossover...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.