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Article

Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha.

The Journal of biological chemistry - 13 Aug 2004

Miyazaki Makoto, Dobrzyn Agnieszka, Sampath Harini, Lee Seong-Ho, Man Weng Chi, Chu Kiki, Peters Jeffrey M, Gonzalez Frank J, Ntambi James M

Abstract excerpt

Stearoyl-CoA desaturase catalyzes the rate-limiting step in the biosynthesis of monounsaturated fatty acids, which are required for normal rates of synthesis of triglycerides, cholesterol esters, and phospholipids. Mice with a targeted disruption of the stearoyl-CoA desaturase 1 (SCD1) isoform are protected against diet and leptin deficiency-induced adiposity, have increased energy expenditure, and have...

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Identifiers

PMID: 15180999
DOI: 10.1074/jbc.M405327200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha.PMID 15180999Read ↗

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