Article
Statins downregulate myeloperoxidase gene expression in macrophages.
Biochemical and biophysical research communications - 3 Jun 2005
Kumar Alan P, Reynolds Wanda F
Abstract excerpt
Statins, inhibitors of HMG-CoA reductase, have pleiotropic benefits independent of cholesterol levels, including anti-oxidant and anti-inflammatory effects. Here, we investigate the effect of statins on myeloperoxidase (MPO) expression. MPO, expressed in foam cell macrophages, was recently shown to oxidize the ApoA-1 component of HDL, impairing ABCA-1 mediated cholesterol efflux. High levels of serum MPO...
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