Article

Treatment of left ventricular dysfunction in dilated cardiomyopathy with a myeloperoxidase inhibitor

2022-11-08

Abstract excerpt

Dilated cardiomyopathy (DCM), an incurable disease of the cardiomyocyte terminating in systolic heart failure (HFrEF), is prevalent, causes hospitalization and is associated with increased mortality. Despite evidence of immune activation in DCM, anti-inflammatory interventions so far did not prove to alter the course of this disease. Here we show that myeloperoxidase (MPO), the principal heme peroxidase expressed...

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Literature Corpus work: c035e46d-f626-5379-8d10-c4a1eab7cfcf
DOI: 10.1101/2022.11.02.22281785

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