Article
Myeloperoxidase, a leukocyte-derived vascular NO oxidase.
Science (New York, N.Y.) - 28 Jun 2002
Eiserich Jason P, Baldus Stephan, Brennan Marie-Luise, Ma Wenxin, Zhang Chunxiang, Tousson Albert, Castro Laura, Lusis Aldons J, Nauseef William M, White C Roger, Freeman Bruce A
Abstract excerpt
Myeloperoxidase (MPO) is an abundant mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions. Although its microbicidal functions are well established in vitro, humans deficient in MPO are not at unusual risk of infection. MPO was observed herein to modulate the vascular signaling and vasodilatory functions of nitric oxide (NO) during acute inflammation. After leukocyte degranulation,...
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