No relationship between neutrophil granulocyte activation and the myeloperoxidase gene - 129 G>A and - 463 G>A promoter polymorphisms: implications for investigations of cardiovascular disease.

Abstract excerpt

OBJECTIVE: Myeloperoxidase catalyzes the formation of reactive oxygen metabolites in neutrophils and monocytes. Increased plasma myeloperoxidase concentrations are linked to coronary artery stenosis and may be useful for risk prediction following acute coronary syndromes. We studied the influence of the - 129 G>A and - 463 G>A myeloperoxidase gene promoter polymorphisms on myeloperoxidase concentrations and...

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