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Article

Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2016

Kolawole Elizabeth Motunrayo, McLeod Jamie Josephine Avila, Ndaw Victor, Abebayehu Daniel, Barnstein Brian O, Faber Travis, Spence Andrew J, Taruselli Marcela, Paranjape Anuya, Haque Tamara T, Qayum Amina A, Kazmi Qasim A, Wijesinghe Dayanjan S, Sturgill Jamie L, Chalfant Charles E, Straus David B, Oskeritzian Carole A, Ryan John J

Abstract excerpt

Mast cell (MC)- and basophil-associated inflammatory diseases are a considerable burden to society. A significant portion of patients have symptoms despite standard-of-care therapy. Statins, used to lower serum cholesterol, have immune-modulating activities. We tested the in vitro and in vivo effects of statins on IgE-mediated MC and basophil activation. Fluvastatin showed the most significant inhibitory effects...

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Identifiers

PMID: 26773154
DOI: 10.4049/jimmunol.1501932
PMCID: PMC4744515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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