Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stressful life events and the serotonin transporter gene (5-HTT) in recurrent clinical depression.

Journal of affective disorders - 1 Jan 2012

Fisher Helen L, Cohen-Woods Sarah, Hosang Georgina M, Uher Rudolf, Powell-Smith Georgia, Keers Robert, Tropeano Maria, Korszun Ania, Jones Lisa, Jones Ian, Owen Mike, Craddock Nick, Craig Ian W, Farmer Anne E, McGuffin Peter

Abstract excerpt

BACKGROUND: An interaction between recent stressful life events (SLEs) and a serotonin transporter promoter polymorphism (5-HTTLPR) in depression has been inconsistently reported. Some of this variability may be due to a previous focus on sub-clinical depression, inclusion of individuals at the lower or upper ends of the age-span, or assumptions concerning the degree of dominance of the low expressing allele....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross-Sectional Studies
Share to Depressive Disorder

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Life Change Events

Share to Models, Genetic

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Share to Recurrence

Share to Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21982504
DOI: 10.1016/j.jad.2011.09.016
PMCID: PMC3272366

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stressful life events and the serotonin transporter gene (5-HTT) in recurrent clinical depression.PMID 21982504Read ↗

The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication.Semantic proximity Read ↗

The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression.Semantic proximity Read ↗

Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health).Semantic proximity Read ↗

Interaction between specific forms of childhood maltreatment and the serotonin transporter gene (5-HTT) in recurrent depressive disorder.Semantic proximity Read ↗

Association of a Triallelic Serotonin Transporter Gene Promoter Region (5-HTTLPR) Polymorphism With Stressful Life Events and Severity of DepressionSemantic proximity Read ↗

Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis.Semantic proximity Read ↗

Life events, first depression onset and the serotonin transporter gene.Semantic proximity Read ↗

Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression.Semantic proximity Read ↗

Interaction between genetic polymorphisms and stressful life events in first episode depression.Semantic proximity Read ↗

5-HTTLPR genotype, stressful life events and late-life depression: no evidence of interaction in a French population.Semantic proximity Read ↗

Variability in the Effect of 5-HTTLPR on Depression in a Large European Population: The Role of Age, Symptom Profile, Type and Intensity of Life StressorsSemantic proximity Read ↗

Serotonin transporter gene as a predictor of stress generation in depression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.