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Article

The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population.

Journal of affective disorders - 1 Apr 2009

Zhang Kerang, Xu Qi, Xu Yong, Yang Hong, Luo Jinxiu, Sun Yan, Sun Ning, Wang Shan, Shen Yan

Abstract excerpt

BACKGROUND: Serotonin transporter (5-HTT) and 5-HT receptor (5-HTR) involved in the neurotransmission of 5-HT may play an important role in the development of major depression disorder (MDD). Several lines of evidence suggested that the gene-environment interaction may confer susceptibility to depression. The aim of this study is to analyze the combined effect of four serotonin-related genes and two environmental...

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Source

Identifiers

PMID: 18848359
DOI: 10.1016/j.jad.2008.07.012

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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