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Article

Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder.

Biological psychiatry - 1 Feb 2006

Surtees Paul G, Wainwright Nicholas W J, Willis-Owen Saffron A G, Luben Robert, Day Nicholas E, Flint Jonathan

Abstract excerpt

BACKGROUND: Recent evidence has suggested that the short allele of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR of the human serotonin gene [SLC6A4]) is associated with increased risk of depressive disorder but only among individuals exposed to social adversity. We report an investigation designed to replicate this finding. METHODS: Data were available from a non-clinical sample of...

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Source

Identifiers

PMID: 16154545
DOI: 10.1016/j.biopsych.2005.07.014

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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