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Article

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.

Science (New York, N.Y.) - 18 Jul 2003

Caspi Avshalom, Sugden Karen, Moffitt Terrie E, Taylor Alan, Craig Ian W, Harrington HonaLee, McClay Joseph, Mill Jonathan, Martin Judy, Braithwaite Antony, Poulton Richie

Abstract excerpt

In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HT T) gene was found to moderate the influence of stressf...

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Source

Identifiers

PMID: 12869766
DOI: 10.1126/science.1083968

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12869766-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.PMID 12869766Read ↗

Interaction between genetic polymorphisms and stressful life events in first episode depression.Semantic proximity Read ↗

Gene-environment interactions in depression research: genetic polymorphisms and life-stress polyprocedures.Semantic proximity Read ↗

Current developments and controversies: does the serotonin transporter gene-linked polymorphic region (5-HTTLPR) modulate the association between stress and depression?Semantic proximity Read ↗

Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis.Semantic proximity Read ↗

Time moderates the interplay between 5-HTTLPR and stress on depression risk: gene x environment interaction as a dynamic process.Semantic proximity Read ↗

The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication.Semantic proximity Read ↗

Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health).Semantic proximity Read ↗

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression.Semantic proximity Read ↗

The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression.Semantic proximity Read ↗

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Interaction between a serotonin transporter gene promoter region polymorphism and stress predicts depressive symptoms in Chinese adolescents: a multi-wave longitudinal study.Semantic proximity Read ↗

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