Article
The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms.
Aging cell - 1 Apr 2006
Fisher Alfred L, Lithgow Gordon J
Abstract excerpt
The orphan nuclear hormone receptor gene daf-12 in Caenorhabditis elegans plays a key role in the regulation of development and determination of adult longevity. To understand the effects of daf-12 on aging we characterized the lifespan of loss-of-function and gain-of-function daf-12 alleles that have been identified on the basis of their effects on dauer development. We find that these mutations have opposing...
Topics
- Amino Acid Sequence
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Down-Regulation
- Fertility
- Gene Expression
- Gene Expression Profiling
- Gene Expression Regulation
- Genes, Helminth
- Longevity
- Molecular Sequence Data
- Mutation
- Oligonucleotide Array Sequence Analysis
- RNA, Messenger
- Receptors, Cytoplasmic and Nuclear