Article
Genes that may modulate longevity in C. elegans in both dauer larvae and long-lived daf-2 adults.
Experimental gerontology - 1 Aug 2007
Ruzanov Peter, Riddle Donald L, Marra Marco A, McKay Sheldon J, Jones Steven M
Abstract excerpt
We used Serial Analysis of Gene Expression (SAGE) to compare the global transcription profiles of long-lived mutant daf-2 adults and dauer larvae, aiming to identify aging-related genes based on similarity of expression patterns. Genes that are expressed similarly in both long-lived types potentially define a common life-extending program. Comparison of eight SAGE libraries yielded a set of 120 genes, the...
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